Flavonoids play diverse roles in plants, comprise a non-negligible fraction of net primary
photosynthetic production, and impart beneficial effects in human health from a plant-based …

The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes
NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation. Most …

The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a
calcium sensor, integrating calcium signaling with other pathways involved in development …

The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ
transplantation. Both compounds are still widely used in the clinic as well as for basic …

The fluorescence quenching measurements and docking studies were used for investigating
the binding of kaempferol and genistein as functional food ingredients to bovine α …

Flavonoids are a large group of polyphenols with numerous biological effects on cancer
cells. They have been shown to affect proliferation via cell cycle arrest, apoptosis and …

Calcineurin (CN), a unique protein phosphatase, plays an important role in immune
regulation. In this study we used CN as a target enzyme to investigate the …

Calcineurin (protein phosphatase 3, Cn) is best known for its central position in Ca2+-
dependent T-cell signaling. Interest in calcineurin has, however, conserved its momentum …

Quercetin, the primary dietary flavonol, exerts a strong inhibitory effect on calcineurin (CN), a
unique Ca2+/calmodulin-dependent serine/threonine protein phosphatase. Using …

Despite the fact that cyclosporin A (CsA) and tacrolimus (FK506) are very potent drugs in the
treatment of serious autoimmune diseases and in the prevention of graft vs. host reactions or …