Causes and consequences of snake venom variation

NR Casewell, TNW Jackson, AH Laustsen… - Trends in …, 2020 - cell.com
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …

Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins

K Suryamohan, SP Krishnankutty, J Guillory, M Jevit… - Nature Genetics, 2020 - nature.com
Snakebite envenoming is a serious and neglected tropical disease that kills~ 100,000
people annually. High-quality, genome-enabled comprehensive characterization of toxin …

History of envenoming therapy and current perspectives

MB Pucca, FA Cerni, R Janke… - Frontiers in …, 2019 - frontiersin.org
Each year, millions of humans fall victim to animal envenomings, which may either be
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …

The urgent need to develop novel strategies for the diagnosis and treatment of snakebites

HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …

The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

[HTML][HTML] Clinical management of snakebite envenoming: future perspectives

M Hamza, C Knudsen, CA Gnanathasan, W Monteiro… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …

[HTML][HTML] Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …