Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Wound healing is a complex biological process that, when impaired, can lead to the
formation of scars. Electrospun nanofibrous wound dressings have emerged as a promising …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this
immune response is commonly observed in tissues during allergic inflammation or infection …