Since its first description more than 20 years ago osteopontin has emerged as an active
player in many physiological and pathological processes, including biomineralization, tissue …

Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …

The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-
term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow …

Background: Potential prognostic biomarker candidates for hepatocellular carcinoma (HCC)
are abundant, but their generalizability is unexplored. We cross-validated markers of overall …

Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular
disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the …

In mammals, few retinal ganglion cells (RGCs) survive following axotomy, and even fewer
regenerate axons. This could reflect differential extrinsic influences or the existence of …

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …

Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …

Complex interactions between tumor and host cells regulate systemic tumor dissemination,
a process that begins early at the primary tumor site and goes on until tumor cells detach …

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …