The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
FSH blockade improves cognition in mice with Alzheimer's disease
Alzheimer's disease has a higher incidence in older women, with a spike in cognitive
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …
Single-cell transcriptomic analysis of Alzheimer's disease
Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …
[HTML][HTML] Physical exercise in the prevention and treatment of Alzheimer's disease
A De la Rosa, G Olaso-Gonzalez… - Journal of sport and …, 2020 - Elsevier
Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …
Alzheimer's pathogenic mechanisms and underlying sex difference
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of …
Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …
consequences of estrogen decline during menopause accelerate neuropathology in …
Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults
Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease
Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …
been recognized for decades, but the contribution of the recently described meningeal …
[HTML][HTML] Sex differences in Alzheimer's disease: insights from the multiomics landscape
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over
the course of disease development. The literature provides some evidence of sex-specific …
the course of disease development. The literature provides some evidence of sex-specific …