Modern network science of neurological disorders

CJ Stam - Nature Reviews Neuroscience, 2014 - nature.com
Modern network science has revealed fundamental aspects of normal brain-network
organization, such as small-world and scale-free patterns, hierarchical modularity, hubs and …

Changing concepts in presurgical assessment for epilepsy surgery

M Zijlmans, W Zweiphenning, N van Klink - Nature Reviews Neurology, 2019 - nature.com
Candidates for epilepsy surgery must undergo presurgical evaluation to establish whether
and how surgical treatment can stop seizures without causing neurological deficits. Various …

Network analysis for a network disorder: the emerging role of graph theory in the study of epilepsy

BC Bernhardt, L Bonilha, DW Gross - Epilepsy & Behavior, 2015 - Elsevier
Recent years have witnessed a paradigm shift in the study and conceptualization of
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …

Interictal stereotactic-EEG functional connectivity in refractory focal epilepsies

S Lagarde, N Roehri, I Lambert, A Trebuchon… - Brain, 2018 - academic.oup.com
Drug-refractory focal epilepsies are network diseases associated with functional connectivity
alterations both during ictal and interictal periods. A large majority of studies on the …

Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery

N Sinha, Y Wang, N Moreira da Silva, A Miserocchi… - Neurology, 2021 - AAN Enterprises
Objective We assessed preoperative structural brain networks and clinical characteristics of
patients with drug-resistant temporal lobe epilepsy (TLE) to identify correlates of postsurgical …

Neuroimaging and connectomics of drug‐resistant epilepsy at multiple scales: From focal lesions to macroscale networks

S Tavakol, J Royer, AJ Lowe, L Bonilha, JI Tracy… - …, 2019 - Wiley Online Library
Epilepsy is among the most common chronic neurologic disorders, with 30%‐40% of
patients having seizures despite antiepileptic drug treatment. The advent of brain imaging …

Structural connectivity differences in left and right temporal lobe epilepsy

P Besson, V Dinkelacker, R Valabregue, L Thivard… - Neuroimage, 2014 - Elsevier
Our knowledge on temporal lobe epilepsy (TLE) with hippocampal sclerosis has evolved
towards the view that this syndrome affects widespread brain networks. Diffusion weighted …

Deep learning applied to whole‐brain connectome to determine seizure control after epilepsy surgery

E Gleichgerrcht, B Munsell, S Bhatia… - …, 2018 - Wiley Online Library
Objective We evaluated whether deep learning applied to whole‐brain presurgical structural
connectomes could be used to predict postoperative seizure outcome more accurately than …

Evaluation of machine learning algorithms for treatment outcome prediction in patients with epilepsy based on structural connectome data

BC Munsell, CY Wee, SS Keller, B Weber, C Elger… - Neuroimage, 2015 - Elsevier
The objective of this study is to evaluate machine learning algorithms aimed at predicting
surgical treatment outcomes in groups of patients with temporal lobe epilepsy (TLE) using …

[HTML][HTML] The impact of epilepsy surgery on the structural connectome and its relation to outcome

PN Taylor, N Sinha, Y Wang, SB Vos, J de Tisi… - NeuroImage: Clinical, 2018 - Elsevier
Background Temporal lobe surgical resection brings seizure remission in up to 80% of
patients, with long-term complete seizure freedom in 41%. However, it is unclear how …