Transaminase biocatalysis: optimization and application
F Guo, P Berglund - Green Chemistry, 2017 - pubs.rsc.org
Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …
Application of ω-Transaminases in the Pharmaceutical Industry
Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
emerged as an exciting option for their synthesis, offering a potential “green alternative” to …
Discovery, engineering, and synthetic application of transaminase biocatalysts
I Slabu, JL Galman, RC Lloyd, NJ Turner - ACS Catalysis, 2017 - ACS Publications
Transaminases have attracted considerable interest in their use as biocatalysts for the
synthesis of compounds containing chiral amine units, which are widespread within the …
synthesis of compounds containing chiral amine units, which are widespread within the …
Microbial enzymes: tools for biotechnological processes
JL Adrio, AL Demain - Biomolecules, 2014 - mdpi.com
Microbial enzymes are of great importance in the development of industrial bioprocesses.
Current applications are focused on many different markets including pulp and paper …
Current applications are focused on many different markets including pulp and paper …
Biocatalytic reduction reactions from a chemist's perspective
F Hollmann, DJ Opperman… - Angewandte Chemie …, 2021 - Wiley Online Library
Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
Multi‐enzymatic cascade reactions: overview and perspectives
E Ricca, B Brucher… - Advanced Synthesis & …, 2011 - Wiley Online Library
Multi‐enzymatic cascade reactions, ie, the combination of several enzymatic transformations
in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs …
in concurrent one‐pot processes, offer considerable advantages: the demand of time, costs …
New generation of biocatalysts for organic synthesis
The use of enzymes as catalysts for the preparation of novel compounds has received
steadily increasing attention over the past few years. High demands are placed on the …
steadily increasing attention over the past few years. High demands are placed on the …
Enzyme-mediated oxidations for the chemist
Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …
ω-Transaminases for the synthesis of non-racemic α-chiral primary amines
D Koszelewski, K Tauber, K Faber, W Kroutil - Trends in biotechnology, 2010 - cell.com
Optically pure amines are highly valuable products or key intermediates for a vast number of
bioactive compounds; however, efficient methods for their preparation are rare. ω …
bioactive compounds; however, efficient methods for their preparation are rare. ω …
Enzymatic reductions for the chemist
When challenged by a difficult reduction reaction, a chemist should always also consider
biocatalysis in synthesis planning. The inherent selectivity of enzymes has been known for …
biocatalysis in synthesis planning. The inherent selectivity of enzymes has been known for …