Understanding osteoarthritis pathogenesis: a multiomics system-based approach
A Ratneswaran, JS Rockel… - Current opinion in …, 2020 - journals.lww.com
To address the complexity of osteoarthritis, integration of multitissue analyses by multiomics
approaches with the inclusion of longitudinal clinical data is necessary for a comprehensive …
approaches with the inclusion of longitudinal clinical data is necessary for a comprehensive …
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review
M Bryk, K Starowicz - Pharmacological Reports, 2021 - Springer
Over the last several decades, the percentage of patients suffering from different forms of
arthritis has increased due to the ageing population and the increasing risk of civilization …
arthritis has increased due to the ageing population and the increasing risk of civilization …
miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis
Q Xia, Q Wang, F Lin, J Wang - Bioengineered, 2021 - Taylor & Francis
ABSTRACT miRNAs are broad participants in vertebrate biological processes, and they are
also the major players in pathological processes. miR-125a-5p was recently found a …
also the major players in pathological processes. miR-125a-5p was recently found a …
Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3
X Chen, Y Shi, P Xue, X Ma, J Li, J Zhang - Arthritis research & therapy, 2020 - Springer
Background Emerging evidence suggests that microRNAs (miRs) are associated with the
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …
Metabolic phenotypes reflect patient sex and injury status: A cross-sectional analysis of human synovial fluid
HD Welhaven, AH Welfley, P Pershad, J Satalich… - Osteoarthritis and …, 2024 - Elsevier
Objective Osteoarthritis is a heterogeneous disease. The objective was to compare
differences in underlying cellular mechanisms and endogenous repair pathways between …
differences in underlying cellular mechanisms and endogenous repair pathways between …
Alterations in anandamide synthesis and degradation during osteoarthritis progression in an animal model
M Bryk, J Chwastek, M Kostrzewa, J Mlost… - International Journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and
chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid …
chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid …
Mitochondrial Role on Cellular Apoptosis, Autophagy, and Senescence during Osteoarthritis Pathogenesis
A Dalmao-Fernández, T Hermida-Gómez… - Cells, 2024 - mdpi.com
Authors have demonstrated that apoptosis activation is a pathway related to cartilage
degradation characteristics of the OA process. Autophagy is an adaptive response to protect …
degradation characteristics of the OA process. Autophagy is an adaptive response to protect …
[HTML][HTML] Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases
L Roseti, G Borciani, E Amore, B Grigolo - International Journal of …, 2024 - mdpi.com
The management of rheumatic diseases has noticeably changed in recent years with the
development of targeted therapeutic agents, namely, biological disease-modifying …
development of targeted therapeutic agents, namely, biological disease-modifying …
CDK9 attenuation exerts protective effects on catabolism and hypertrophy in chondrocytes and ameliorates osteoarthritis development
S Xue, L Zhu, C Wang, Y Jiang, H Lu, Y Liu… - Biochemical and …, 2019 - Elsevier
Osteoarthritis (OA) is generally considered to be characterized by progressive articular
cartilage destruction. Increasing evidence demonstrates that CDK9, which is a member of …
cartilage destruction. Increasing evidence demonstrates that CDK9, which is a member of …
Subchondral bone structure and synovial fluid metabolism are altered in injured and contralateral limbs 7 days after non-invasive joint injury in skeletally-mature …
Objective Post-traumatic osteoarthritis (PTOA) commonly develops after ACL injury, but early
changes to the joint soon after injury are insufficiently understood. The objectives of this …
changes to the joint soon after injury are insufficiently understood. The objectives of this …