The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone.
ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs) …

Spermatogenesis is an intriguing but complicated biological process. However, many
studies since the 1960s have focused either on the hormonal events of the hypothalamus …

THAT the testes are related to the sexual characteristics of the individual and have
reproductive power was observed at an early time in history. One of the earliest descriptions …

Cytokines are regulatory proteins involved in haematopoiesis, immune cell development,
inflammation and immune responses. Several cytokines have direct effects on testicular cell …

Five main cell types are present in the Leydig cell lineage, namely the mesenchymal
precursor cells, progenitor cells, newly formed adult Leydig cells, immature Leydig cells, and …

II. Neurohormones/Neuropeptides A. GH-releasing hormone (GHRH) B. Pituitary adenylate
cyclase-activating peptide (PACAP)

BACKGROUND Leydig cells (LC) are the sites of testicular androgen production.
Development of LC occurs in the testes of most mammalian species as two distinct growth …

Publisher Summary This chapter discusses the sertoli–germ cell communication network in
mammals. In most mammals, spermatogenesis occurs in the seminiferous tubules, which …