ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
Forty years of clathrin‐coated vesicles
MS Robinson - Traffic, 2015 - Wiley Online Library
The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
J Birnbaum, S Scharf, S Schmidt, E Jonscher… - Science, 2020 - science.org
Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms
JK Fink - Acta neuropathologica, 2013 - Springer
Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited
disorders in which lower extremity weakness and spasticity are the predominant symptoms …
disorders in which lower extremity weakness and spasticity are the predominant symptoms …
[HTML][HTML] Coordinated transcription of key pathways in the mouse by the circadian clock
In mammals, circadian control of physiology and behavior is driven by a master pacemaker
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …
Signals for sorting of transmembrane proteins to endosomes and lysosomes
JS Bonifacino, LM Traub - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …
signals present within the cytosolic domains of the proteins. Most signals consist of short …
[HTML][HTML] Sorting of lysosomal proteins
T Braulke, JS Bonifacino - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …
Trafficking and function of the tetraspanin CD63
MS Pols, J Klumperman - Experimental cell research, 2009 - Elsevier
Tetraspanins comprise a large superfamily of cell surface-associated membrane proteins
characterized by four transmembrane domains. They participate in a variety of cellular …
characterized by four transmembrane domains. They participate in a variety of cellular …
Adaptable adaptors for coated vesicles
MS Robinson - Trends in cell biology, 2004 - cell.com
Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …
Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization
mRNAs are transported, localized, and translated in axons of sensory neurons. However,
little is known about the full repertoire of transcripts present in embryonic and adult sensory …
little is known about the full repertoire of transcripts present in embryonic and adult sensory …