Challenges and issues with streptozotocin-induced diabetes–a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics
Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways
K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …
population. Both experimental and clinical evidence suggest that diabetic subjects are …
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
RL Montgomery, MJ Potthoff… - The Journal of …, 2008 - Am Soc Clin Investig
Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety of
disorders, including cancer, neurological disease, and cardiac hypertrophy. However, the …
disorders, including cancer, neurological disease, and cardiac hypertrophy. However, the …
SIRT-3 modulation by resveratrol improves mitochondrial oxidative phosphorylation in diabetic heart through deacetylation of TFAM
Background and Purpose: Mitochondrial dysfunction remains the crucial cause for many
heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein …
heart diseases including diabetic cardiomyopathy (DCM). Sirtuin-3 (SIRT-3) is a protein …
Diabetic cardiomyopathy--fact or fiction?
Epidemiologic as well as clinical studies confirm the close link between diabetes mellitus
and heart failure. Diabetic cardiomyopathy (DCM) is still a poorly understood" entity" …
and heart failure. Diabetic cardiomyopathy (DCM) is still a poorly understood" entity" …
Single-droplet multiplex bioassay on a robust and stretchable extreme wetting substrate through vacuum-based droplet manipulation
Herein, a droplet manipulation system with a superamphiphobic (SPO)–superamphiphilic
(SPI) patterned polydimethylsiloxane (PDMS) substrate is developed for a multiplex …
(SPI) patterned polydimethylsiloxane (PDMS) substrate is developed for a multiplex …
Mitochondrial stress and the pathogenesis of diabetic neuropathy
P Fernyhough, SK Roy Chowdhury… - Expert review of …, 2010 - Taylor & Francis
Diabetic neuropathy is a major complication of diabetes that affects the sensory and
autonomic nervous systems and leads to significant morbidity and impact on the quality of …
autonomic nervous systems and leads to significant morbidity and impact on the quality of …
Murine models of diastolic dysfunction and heart failure with preserved ejection fraction
Left ventricular diastolic dysfunction leads to heart failure with preserved ejection fraction, an
increasingly prevalent condition largely driven by modern day lifestyle risk factors. As heart …
increasingly prevalent condition largely driven by modern day lifestyle risk factors. As heart …
Inhibition of dipeptidyl peptidase-4 impairs ventricular function and promotes cardiac fibrosis in high fat–fed diabetic mice
Dipeptidyl peptidase-4 (DPP4) inhibitors used for the treatment of type 2 diabetes are
cardioprotective in preclinical studies; however, some cardiovascular outcome studies …
cardioprotective in preclinical studies; however, some cardiovascular outcome studies …
Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location
CL Williamson, ER Dabkowski… - American Journal …, 2010 - journals.physiology.org
Cardiovascular complications, such as diabetic cardiomyopathy, account for the majority of
deaths associated with diabetes mellitus. Mitochondria are particularly susceptible to the …
deaths associated with diabetes mellitus. Mitochondria are particularly susceptible to the …