The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

In the last 20 years, it has become clear that developmental genes and their regulators,
noncoding RNAs including microRNAs and long-noncoding RNAs, within signaling …

The bones in your face, the pigment in your skin and the neural circuitry that controls your
digestive tract have one thing in common: they are all derived from neural crest cells. The …

The Zic family of zinc-finger proteins plays a crucial role in neural development. Zic genes
are vertebrate homologs of odd-paired, the Drosophila pair-rule gene. Their gene products …

Abstract Dandy-Walker malformation (DWM; OMIM# 220200) is a common but poorly
understood congenital cerebellar malformation in humans. Through physical mapping of …

The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a
range of 1012 in pressure, and discriminating both infrasonic and ultrasonic frequencies in …

The highly orchestrated processes that generate the vertebrate inner ear from the otic
placode provide an excellent and circumscribed testing ground for fundamental cellular and …

Background The transcription factor Atoh1/Hath1 plays crucial roles in the differentiation
program of human intestinal epithelium cells (IECs). Although previous studies have …

Atoh1 (also known as Math1, Hath1, and Cath1 in mouse, human, and chicken, respectively)
is a proneural basic helix–loop–helix (bHLH) transcription factor that is required in a variety …

The molecular control of cell-type specification within the developing cerebellum as well as
the genetic causes of the most common human developmental cerebellar disorders have …