Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Biomedical engineers have traditionally developed technologies in response to the needs of
the developed world's medical community. As a result, the diagnostic systems on which they …

Background New diagnostic tools are urgently needed to interrupt the transmission of
tuberculosis and multidrug-resistant tuberculosis. Rapid, sensitive detection of tuberculosis …

ABSTRACT WHO-endorsed phenotypic drug susceptibility testing (DST) methods for
Mycobacterium tuberculosis are assumed to be the gold standard for identifying rifampin …

Tuberculosis is the main cause of morbidity and mortality in people living with HIV/AIDS
worldwide. Early diagnosis and treatment is essential to addressing the dual epidemic of …

Although the human immunodeficiency virus (HIV) infection pandemic has had a
catastrophic impact on tuberculosis (TB) control efforts, especially in sub-Saharan Africa …

Nearly a third of the world's population is estimated to be infected with Mycobacterium
tuberculosis. This enormous pool of latently infected individuals poses a major hurdle for …

Background One of the challenges facing the tuberculosis (TB) control programmes in
resource-limited settings is lack of rapid techniques for detection of drug resistant TB …

Human immunodeficiency virus (HIV) associated tuberculosis (TB) remains a major global
public health challenge, with an estimated 1.4 million patients worldwide. Co-infection with …

Background The “fitness” of an infectious pathogen is defined as the ability of the pathogen
to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant …