The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused
by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations …

Abstract von Hippel–Lindau (VHL) disease is an inheritable condition with an incidence of 1
in 36 000 live births. Individuals with VHL develop benign and malignant tumors including …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia
syndromes and is characterized by highly vascular tumors of the eyes, brain, and spine, as …

Inherited susceptibility to kidney cancer is a fascinating and complex topic. Our knowledge
about types of genetic syndromes associated with an increased risk of disease is continually …

Abstract von Hippel‐Lindau disease (VHL) is an inherited neoplastic disorder characterized
by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland …

Neuroendocrine tumors arising from the adrenal medulla and extra-adrenal ganglia are
called pheochromocytomas and paragangliomas (PCCs/PGLs), respectively. PCCs/PGLs …

Abstract von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germ
line mutation of the von Hippel-Lindau tumor suppressor gene (VHL). Tumors observed in …

Abstract The von Hippel-Lindau tumour suppressor gene product (pVHL) associates with the
elongin B and C and Cul2 proteins to form a ubiquitin-ligase complex (VCBC). To date, the …

Context: Pheochromocytomas and paragangliomas (PHEO/PGL) are neuroendocrine
tumors that arise from sympathetic and parasympathetic paraganglia. Diagnosed rarely …