A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …

The nematode Caenorhabditis elegans is now a major model organism in biology. The
choice of Sydney Brenner to adopt this species in the mid-1960s and the success of his …

The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has
remained unknown whether not only lesion-type-specific, but overall repair capacities could …

We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

Oncosis (from Greek ónkos, meaning “swelling”) is a non-apoptotic cell death process
related to energy depletion. In contrast to apoptosis, which is the main form of cell death …

ROS (reactive oxygen species) are potentially damaging by-products of aerobic metabolism
which, unchecked, can have detrimental effects on cell function. However, it is now widely …

A series of rhenium (I) complexes of the type fac-[Re (CO) 3 (N^ N) L] 0/+, Re1–Re9, was
synthesized, where N^ N= benzimidazole-derived bidentate ligand with an ester …

Invertebrate animals have been used as medicinals for 4,000 years and have served as
models for research and teaching since the late 1800s. Interest in invertebrate models has …

Caenorhabditis elegans (C. elegans) nematodes are a powerful model organism for diverse
biological and biomedical studies, benefiting from their genetic similarities to humans, small …

Plants/plant-derived components have been used from ancient times to treat/cure several
human diseases. Plants and their parts possess several chemical components that play the …