Acetylcholine muscarinic M4 receptors as a therapeutic target for alcohol use disorder: converging evidence from humans and rodents

LC Walker, AE Berizzi, NA Chen, P Rueda… - Biological …, 2020 - Elsevier
Background Alcohol use disorder (AUD) is a major socioeconomic burden on society, and
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and …

RLN3/RXFP3 signaling in the PVN inhibits magnocellular neurons via M-like current activation and contributes to binge eating behavior

A Kania, A Szlaga, P Sambak, A Gugula… - Journal of …, 2020 - Soc Neuroscience
Binge-eating disorder is the most common eating disorder. Various neuropeptides play
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

I Gil-Miravet, A Mañas-Ojeda, F Ros-Bernal… - Frontiers in …, 2021 - frontiersin.org
Telencephalic cognitive and emotional circuits/functions are strongly modulated by
subcortical inputs. The main focus of past research on the nature of this modulation has …

Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking

LC Walker, LJ Hand, B Letherby, KL Huckstep… - …, 2021 - nature.com
The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating
alcohol and stress interactions. However, the exact neuronal populations that govern this …

Organisation of enkephalin inputs and outputs of the central nucleus of the amygdala in mice

A Viden, SS Ch'ng, LC Walker, A Shesham… - Journal of Chemical …, 2022 - Elsevier
The central nucleus of the amygdala (CeA) is a key hub integrating sensory inputs and
modulating behavioural outputs. The CeA is a complex structure with discrete subdivisions …

Electrophysiologically distinct bed nucleus of the stria terminalis projections to the ventral tegmental area in mice

Y Miura, MR Shanley, A Urbaez… - Frontiers in Neural …, 2023 - frontiersin.org
The bed nucleus of the stria terminalis (BNST) is a highly heterogeneous limbic forebrain
structure that serves as a relay connecting autonomic, neuroendocrine and behavioral …

Hypothalamic-hindbrain circuit for consumption-induced fear regulation

Q Wang, RY Sun, JX Hu, YH Sun, CY Li… - Nature …, 2024 - nature.com
To ensure survival, animals must sometimes suppress fear responses triggered by potential
threats during feeding. However, the mechanisms underlying this process remain poorly …

Muscarinic M4 and M5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol‐preferring rats

LC Walker, KL Huckstep, NA Chen… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Muscarinic acetylcholine receptors mediate alcohol consumption
and seeking in rats. While M4 and M5 receptors have recently been implicated to mediate …

Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior

JT McKenna, C Yang, T Bellio… - Brain Structure and …, 2021 - Springer
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role
of individual BF neuronal subtypes is still being uncovered. Glutamatergic neurons are the …

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model

WW Yan, M Xia, J Chiang, A Levitt, N Hawkins… - Eneuro, 2021 - eneuro.org
Dravet syndrome (DS) is a developmental and epileptic encephalopathy with an increased
incidence of sudden death. Evidence of interictal breathing deficits in DS suggests that …