Acetylcholine muscarinic M4 receptors as a therapeutic target for alcohol use disorder: converging evidence from humans and rodents
Background Alcohol use disorder (AUD) is a major socioeconomic burden on society, and
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and …
current pharmacotherapeutic treatment options are inadequate. Aberrant alcohol use and …
RLN3/RXFP3 signaling in the PVN inhibits magnocellular neurons via M-like current activation and contributes to binge eating behavior
A Kania, A Szlaga, P Sambak, A Gugula… - Journal of …, 2020 - Soc Neuroscience
Binge-eating disorder is the most common eating disorder. Various neuropeptides play
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
I Gil-Miravet, A Mañas-Ojeda, F Ros-Bernal… - Frontiers in …, 2021 - frontiersin.org
Telencephalic cognitive and emotional circuits/functions are strongly modulated by
subcortical inputs. The main focus of past research on the nature of this modulation has …
subcortical inputs. The main focus of past research on the nature of this modulation has …
Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking
LC Walker, LJ Hand, B Letherby, KL Huckstep… - …, 2021 - nature.com
The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating
alcohol and stress interactions. However, the exact neuronal populations that govern this …
alcohol and stress interactions. However, the exact neuronal populations that govern this …
Organisation of enkephalin inputs and outputs of the central nucleus of the amygdala in mice
The central nucleus of the amygdala (CeA) is a key hub integrating sensory inputs and
modulating behavioural outputs. The CeA is a complex structure with discrete subdivisions …
modulating behavioural outputs. The CeA is a complex structure with discrete subdivisions …
Electrophysiologically distinct bed nucleus of the stria terminalis projections to the ventral tegmental area in mice
Y Miura, MR Shanley, A Urbaez… - Frontiers in Neural …, 2023 - frontiersin.org
The bed nucleus of the stria terminalis (BNST) is a highly heterogeneous limbic forebrain
structure that serves as a relay connecting autonomic, neuroendocrine and behavioral …
structure that serves as a relay connecting autonomic, neuroendocrine and behavioral …
Hypothalamic-hindbrain circuit for consumption-induced fear regulation
Q Wang, RY Sun, JX Hu, YH Sun, CY Li… - Nature …, 2024 - nature.com
To ensure survival, animals must sometimes suppress fear responses triggered by potential
threats during feeding. However, the mechanisms underlying this process remain poorly …
threats during feeding. However, the mechanisms underlying this process remain poorly …
Muscarinic M4 and M5 receptors in the ventral subiculum differentially modulate alcohol seeking versus consumption in male alcohol‐preferring rats
Background and Purpose Muscarinic acetylcholine receptors mediate alcohol consumption
and seeking in rats. While M4 and M5 receptors have recently been implicated to mediate …
and seeking in rats. While M4 and M5 receptors have recently been implicated to mediate …
Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior
JT McKenna, C Yang, T Bellio… - Brain Structure and …, 2021 - Springer
The basal forebrain (BF) is involved in arousal, attention, and reward processing but the role
of individual BF neuronal subtypes is still being uncovered. Glutamatergic neurons are the …
of individual BF neuronal subtypes is still being uncovered. Glutamatergic neurons are the …
Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model
WW Yan, M Xia, J Chiang, A Levitt, N Hawkins… - Eneuro, 2021 - eneuro.org
Dravet syndrome (DS) is a developmental and epileptic encephalopathy with an increased
incidence of sudden death. Evidence of interictal breathing deficits in DS suggests that …
incidence of sudden death. Evidence of interictal breathing deficits in DS suggests that …