When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Emerging evidence supports an important, etiologic role for epigenetic modifications in
cancer. Various post translational modifications of histone proteins together with DNA …

Histone tails play an important role in gene transcription and expression. We present here a
systematic computational study of the role of histone tails in the nucleosome, using replica …

Legionella pneumophila replicates intracellularly by secreting effectors via a type IV
secretion system. One of these effectors is a eukaryotic methyltransferase (RomA) that …

Chromatin compaction and gene accessibility are orchestrated by assembly and
disassembly of nucleosomes. Although the disassembly process was widely studied, little is …

Advances in engineered recombinant nuclease have provided facile and reliable methods
for genome editing. Especially with the development of the CRISPR (clustered regularly …

Until recently, a major limitation of hydrogen-deuterium exchange mass spectrometry (HDX-
MS) was that resolution of deuterium localization was limited to the length of the peptide …

Prokaryotes have developed numerous innate immune mechanisms in order to fend off
bacteriophage or plasmid attack. One of these immune systems is clustered regularly …

The most popular model of gene activation by remote enhancers postulates that the
enhancers interact directly with target promoters via the looping of intervening DNA …

The nucleosome, which organizes the long coil of genomic DNA in a highly condensed,
polymeric way, is thought to be the basic unit of chromosomal structure. As the most …