The brain is one of the most energy-consuming organs in the mammalian body, and
synaptic transmission is one of the major contributors. To meet these energetic …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

The normal aging human brain experiences global decreases in metabolism, but whether
this affects the topography of brain metabolism is unknown. Here we describe PET-based …

Sex differences influence brain morphology and physiology during both development and
aging. Here we apply a machine learning algorithm to a multiparametric brain PET imaging …

Sexual differentiation of the brain during early development likely underlies the strong sex
biases prevalent in many neurological conditions. Mounting evidence indicates that …

Young women exhibit higher prevalence of orthostatic hypotension with presyncopal
symptoms compared to men. These symptoms could be influenced by an attenuated ability …

Microglia are the resident immune cells in the brain and maintain homeostasis and
functionality of this tissue. These cells are key producers of immune mediators, such as …

Active exercise for upper limb training has been widely used to improve hemiplegic upper
limb function, and its effect may be boosted by extrinsic visual feedback. The passive …

Background: Animal and human experiments have confirmed sex differences in the
expression of hepatic enzymes that metabolize antipsychotic drugs and that may, in this …

The requirements of metabolizing tissue are both continuous and variable; accordingly, the
microvasculature serving that tissue must be similarly dynamic. Just as it is recognized that …