Primary cancer cell lines are ex vivo cell cultures originating from resected tissues during
biopsies and surgeries. Primary cell cultures are objects of intense research due to their …

Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic
instability in breast cancer leads to mutations, copy number variations, and genetic …

Simple Summary Current data suggest that epigenetic alterations are involved in the
initiation and subclonal evolution of breast cancer. During cancer progression, the …

Epigenetic research involves examining the mitotically heritable processes that regulate
gene expression, independent of changes in the DNA sequence. Recent technical …

Breast cancer has the highest incidence among all malignancies diagnosed in women.
Therapies have significantly improved over the years due to extensive molecular and clinical …

The cell cycle is a complex and strictly controlled process, consisting of different phases.
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The …

At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …

In the recent years the rapid scientific innovation in the evaluation of the individual's genome
have allowed the identification of variants associated with the onset, treatment and …

Current research on triple-negative breast cancer (TNBC) has resulted in delineation into
the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as …