[HTML][HTML] Sixty years of amphotericin B: an overview of the main antifungal agent used to treat invasive fungal infections
FB Cavassin, JL Baú-Carneiro, RR Vilas-Boas… - Infectious Diseases and …, 2021 - Springer
Introduced in the late 1950s, polyenes represent the oldest family of antifungal drugs. The
discovery of amphotericin B and its therapeutic uses is considered one of the most important …
discovery of amphotericin B and its therapeutic uses is considered one of the most important …
[HTML][HTML] Molecular evolution of antifungal drug resistance
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species
C Paulussen, JE Hallsworth… - Microbial …, 2017 - Wiley Online Library
Fungi of the genus Aspergillus are widespread in the environment. Some Aspergillus
species, most commonly Aspergillus fumigatus, may lead to a variety of allergic reactions …
species, most commonly Aspergillus fumigatus, may lead to a variety of allergic reactions …
[HTML][HTML] Lipid systems for the delivery of amphotericin B in antifungal therapy
C Faustino, L Pinheiro - Pharmaceutics, 2020 - mdpi.com
Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …
years, remains the gold standard in the treatment of life-threatening invasive fungal …
New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics
J Geddes‐McAlister, RS Shapiro - … of the New York Academy of …, 2019 - Wiley Online Library
Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
becomes increasingly common, fungal infections are becoming more prevalent. The use of …
Resistance to antifungal drugs
R Ben-Ami, DP Kontoyiannis - Infectious Disease Clinics, 2021 - id.theclinics.com
The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …
underappreciated, with estimates indicating as many as 150 million persons infected …
The production of reactive oxygen species is a universal action mechanism of amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this …
AC Mesa-Arango, N Trevijano-Contador… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the
cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of …
cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of …
[HTML][HTML] The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence
V Valiante, J Macheleidt, M Föge… - Frontiers in …, 2015 - frontiersin.org
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …
Aspergillus fumigatus and aspergillosis: From basics to clinics
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …
causing numerous invasive infections and a notable mortality in humans, especially in …
[HTML][HTML] Drug resistance in eukaryotic microorganisms
Eukaryotic microbial pathogens are major contributors to illness and death globally.
Although much of their impact can be controlled by drug therapy as with prokaryotic …
Although much of their impact can be controlled by drug therapy as with prokaryotic …