Prophylactic and therapeutic drugs are urgently needed to combat coronavirus disease
2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had
become a global concern because of its unexpectedly high pathogenicity and …

Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …

Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …

Current COVID-19 vaccines and many clinical diagnostics are based on the structure and
function of the SARS-CoV-2 spike ectodomain. Using hydrogen–deuterium exchange …

Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural
determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins …

Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …

Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-
binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody …

Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …

The current COVID-19 pandemic, caused by SARS-CoV-2, poses a serious public health
threat. Effective therapeutic and prophylactic treatments are urgently needed. Angiotensin …