Rare genetic diseases are a group of pathologies with often unmet clinical needs. Even if
rare by a single genetic disease (from 1/2000 to 1/more than 1,000,000), the total number of …

Abstract Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …

In the brain and cognitive reserves framework, aerobic exercise is considered as a
protective lifestyle factor able to induce positive effects on both brain structure and function …

It is well known that physical exercise has positive effects on cognitive functions and
hippocampal plasticity. However, the underlying mechanisms have remained to be further …

Type 1 diabetes mellitus (T1DM) progressively affects cognitive domains, increases blood–
brain barrier (BBB) permeability and promotes neurovascular impairment in specific brain …

Maca has been used as a foodstuff and a traditional medicine in the Andean region for over
2,000 years. Recently the neuroprotective effects of maca also arouse interest of …

Previous literature suggests that learning and memory formation can be influenced by diet
and exercise. In the current study, we investigated the combined effects of forced swimming …

In cardiomyocytes, intracellular calcium (Ca2+) transients are elicited by electrical and
receptor stimulations, leading to muscle contraction and gene expression, respectively …

Women who have bilateral oophorectomies prior to the age of natural menopause are at
increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type …

Although it is well known that regular exercise may promote neuroprotection, the
mechanisms underlying this effect are still not fully understood. We investigated if swim …