Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

The sympathetic nervous system drives brown and beige adipocyte thermogenesis through
the release of noradrenaline from local axons. However, the molecular basis of higher levels …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …

In brain, signaling mediated by cell adhesion molecules defines the identity and functional
properties of synapses. The specificity of presynaptic and postsynaptic interactions that is …

Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …

NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions
in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human …

GABAB receptors, the most abundant inhibitory G protein–coupled receptors in the
mammalian brain, display pronounced diversity in functional properties, cellular signaling …