Criticality is the singular state of complex systems poised at the brink of a phase transition
between order and randomness. Such systems display remarkable information-processing …

Brain function is a product of the balance between excitatory and inhibitory (E/I) brain
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …

Complete locked-in syndrome (CLIS) resulting from late-stage amyotrophic lateral sclerosis
(ALS) is characterised by loss of motor function and eye movements. The absence of …

Autism is a neurodevelopmental condition that has been related to an overall imbalance
between the brain's excitatory (E) and inhibitory (I) systems. Such an EI imbalance can lead …

Network hyperexcitability (NH) is an important feature of the pathophysiology of Alzheimer's
disease. Functional connectivity (FC) of brain networks has been proposed as a potential …

Does the brain optimize itself for storage and transmission of information, and if so, how?
The critical brain hypothesis is based in statistical physics and posits that the brain self-tunes …

Stroke-related disruptions in functional connectivity (FC) often spread beyond lesioned
areas and, given the localized nature of lesions, it is unclear how the recovery of FC is …

Neuronal activity gives rise to behavior, and behavior influences neuronal dynamics, in a
closed-loop control system. Is it possible then, to find a relationship between the statistical …

A novel network version of permutation entropy, the inverted joint permutation entropy
(JPEinv), holds potential as non-invasive biomarker of abnormal excitation-inhibition (EI) …

Highlights•Different forms of cognitive flexibility show dissociable developmental
trajectories.•An adolescent-specific mode of flexibility scaffolds adult-like cognitive …