An airway protection program revealed by sweeping genetic control of vagal afferents
SL Prescott, BD Umans, EK Williams, RD Brust… - Cell, 2020 - cell.com
Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of
laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and …
laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and …
Cellular diversity and regeneration in taste buds
Taste buds are the sensory end organs for gustation, mediating sensations of salty, sour,
bitter, sweet and umami as well as other possible modalities, for example, fat and kokumi …
bitter, sweet and umami as well as other possible modalities, for example, fat and kokumi …
Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations
MJ Klimara, DR Randall, J Allen… - Annals of the New …, 2020 - Wiley Online Library
Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric
upper and lower airway diseases. However, the diagnosis of proximal reflux–associated …
upper and lower airway diseases. However, the diagnosis of proximal reflux–associated …
Sensory innervation of the larynx and the search for mucosal mechanoreceptors
AG Foote, SL Thibeault - Journal of Speech, Language, and Hearing …, 2021 - ASHA
Purpose The larynx is a uniquely situated organ, juxtaposed between the gastrointestinal
and respiratory tracts, and endures considerable immunological challenges while providing …
and respiratory tracts, and endures considerable immunological challenges while providing …
Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges
AG Foote, J Tibbetts, SM Bartley… - Laryngoscope …, 2022 - Wiley Online Library
Objective The primary aim of this study was to identify expression of TRPV3 and TRPV4
chemoreceptors across perinatal and adult stages using a murine model with direct …
chemoreceptors across perinatal and adult stages using a murine model with direct …
Assessment of laryngeal sensory function using a tactile aesthesiometer in healthy adults
Y Ma, J Kidane, GE Gochman, DJ Bracken… - The …, 2023 - Wiley Online Library
Introduction Laryngeal sensory function in healthy adults was assessed through the delivery
of tactile stimuli using Cheung–Bearelly monofilaments. Methods 37 healthy adults were …
of tactile stimuli using Cheung–Bearelly monofilaments. Methods 37 healthy adults were …
Addressing cancer anorexia-cachexia in older patients: potential therapeutic strategies and molecular pathways
T Ispoglou, D McCullough, A Windle, S Nair, N Cox… - Clinical Nutrition, 2024 - Elsevier
Cancer cachexia (CC) syndrome, a feature of cancer-associated muscle wasting, is
particularly pronounced in older patients, and is characterised by decreased energy intake …
particularly pronounced in older patients, and is characterised by decreased energy intake …
Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation
Mechanoreceptors are implicated as functional afferents within mucosa of the airways and
the recent discovery of mechanosensitive channels Piezo1 and Piezo2 has proved essential …
the recent discovery of mechanosensitive channels Piezo1 and Piezo2 has proved essential …
Laryngeal chemoreflex in health and disease: a review
The larynx plays a key role in airway protection via the laryngeal chemoreflex (LCR). This
involuntary reflex can be evoked when hazardous substances activate mucosal receptors …
involuntary reflex can be evoked when hazardous substances activate mucosal receptors …
Examining the influence of chemosensation on laryngeal health and disorders
CK Novaleski, RL Doty, AA Nolden, PM Wise… - Journal of Voice, 2023 - Elsevier
Inhaled airborne stimuli are associated with laryngeal disorders affecting respiration.
Clinically, several themes emerged from the literature that point to specific gaps in the …
Clinically, several themes emerged from the literature that point to specific gaps in the …