An airway protection program revealed by sweeping genetic control of vagal afferents

SL Prescott, BD Umans, EK Williams, RD Brust… - Cell, 2020 - cell.com
Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of
laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and …

Cellular diversity and regeneration in taste buds

TE Finger, LA Barlow - Current opinion in physiology, 2021 - Elsevier
Taste buds are the sensory end organs for gustation, mediating sensations of salty, sour,
bitter, sweet and umami as well as other possible modalities, for example, fat and kokumi …

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

MJ Klimara, DR Randall, J Allen… - Annals of the New …, 2020 - Wiley Online Library
Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric
upper and lower airway diseases. However, the diagnosis of proximal reflux–associated …

Sensory innervation of the larynx and the search for mucosal mechanoreceptors

AG Foote, SL Thibeault - Journal of Speech, Language, and Hearing …, 2021 - ASHA
Purpose The larynx is a uniquely situated organ, juxtaposed between the gastrointestinal
and respiratory tracts, and endures considerable immunological challenges while providing …

Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges

AG Foote, J Tibbetts, SM Bartley… - Laryngoscope …, 2022 - Wiley Online Library
Objective The primary aim of this study was to identify expression of TRPV3 and TRPV4
chemoreceptors across perinatal and adult stages using a murine model with direct …

Assessment of laryngeal sensory function using a tactile aesthesiometer in healthy adults

Y Ma, J Kidane, GE Gochman, DJ Bracken… - The …, 2023 - Wiley Online Library
Introduction Laryngeal sensory function in healthy adults was assessed through the delivery
of tactile stimuli using Cheung–Bearelly monofilaments. Methods 37 healthy adults were …

Addressing cancer anorexia-cachexia in older patients: potential therapeutic strategies and molecular pathways

T Ispoglou, D McCullough, A Windle, S Nair, N Cox… - Clinical Nutrition, 2024 - Elsevier
Cancer cachexia (CC) syndrome, a feature of cancer-associated muscle wasting, is
particularly pronounced in older patients, and is characterised by decreased energy intake …

Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation

AG Foote, V Lungova, SL Thibeault - Cellular and Molecular Life Sciences, 2022 - Springer
Mechanoreceptors are implicated as functional afferents within mucosa of the airways and
the recent discovery of mechanosensitive channels Piezo1 and Piezo2 has proved essential …

Laryngeal chemoreflex in health and disease: a review

S Pathak, L Slovarp, MS Clary, ME Jetté - Chemical Senses, 2020 - academic.oup.com
The larynx plays a key role in airway protection via the laryngeal chemoreflex (LCR). This
involuntary reflex can be evoked when hazardous substances activate mucosal receptors …

Examining the influence of chemosensation on laryngeal health and disorders

CK Novaleski, RL Doty, AA Nolden, PM Wise… - Journal of Voice, 2023 - Elsevier
Inhaled airborne stimuli are associated with laryngeal disorders affecting respiration.
Clinically, several themes emerged from the literature that point to specific gaps in the …