Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application

K Zha, X Li, Z Yang, G Tian, Z Sun, X Sui… - NPJ Regenerative …, 2021 - nature.com
Articular cartilage is susceptible to damage but hard to self-repair due to its avascular
nature. Traditional treatment methods are not able to produce satisfactory effects …

The issue of heterogeneity of MSC-based advanced therapy medicinal products–a review

AB Česnik, U Švajger - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous
clinical applications due to their unique properties including self-renewal …

Cd10-Bound human mesenchymal stem/stromal cell-derived small extracellular vesicles possess immunomodulatory cargo and maintain cartilage homeostasis under …

D Kouroupis, LD Kaplan, J Huard, TM Best - Cells, 2023 - mdpi.com
The onset and progression of human inflammatory joint diseases are strongly associated
with the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain …

Mesenchymal stem cells: from identification and characterization to clinical applications

M Alvarez-Viejo, KH Haider - Handbook of stem cell therapy, 2022 - Springer
Since Friedenstein and co-workers first reported bone marrow-derived mesenchymal stem
cells (MSCs) during the early 1970s, several researchers have focused on their biology and …

Single-cell RNA-seq highlights heterogeneity in human primary Wharton's jelly mesenchymal stem/stromal cells cultured in vitro

C Sun, L Wang, H Wang, T Huang, W Yao, J Li… - Stem Cell Research & …, 2020 - Springer
Background Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising
application potential in regenerative medicine and immunomodulation. However, MSCs …

[HTML][HTML] Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation

MR Showalter, B Wancewicz, O Fiehn… - Biochemical and …, 2019 - Elsevier
Mesenchymal stem cell (MSC) based therapies are currently being evaluated as a putative
therapeutic in numerous human clinical trials. Recent reports have established that …

Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies

K Zha, Y Yang, G Tian, Z Sun, Z Yang… - Stem cells …, 2021 - academic.oup.com
Mesenchymal stem/stromal cells (MSCs) are promising for the treatment of degenerative
diseases and traumatic injuries. However, MSC engraftment is not always successful and …

Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells

N Cuesta-Gomez, GJ Graham… - Journal of translational …, 2021 - Springer
Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the
treatment of inflammatory and degenerative disorders due to their anti-inflammatory …

The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony‐Forming Unit‐Fibroblast Assay and the CD45lowCD271+ …

P Ganguly, JJ El-Jawhari, AN Burska… - Stem cells …, 2019 - Wiley Online Library
Uncultured mesenchymal stromal cells (MSCs) are increasingly used in therapies; however,
the effects of donor age on their biological characteristics and gene expression remain …

Research progress on stem cell therapies for articular cartilage regeneration

S Jiang, G Tian, X Li, Z Yang, F Wang… - Stem cells …, 2021 - Wiley Online Library
Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and
mental health of patients. Unfortunately, current surgical treatment techniques that are …