Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

Interindividual differences in drug disposition are important causes for adverse drug
reactions and lack of drug response. The majority of phase I and phase II drug-metabolizing …

Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

A critical review of the limited available evidence and the authors' experience and judgment
are used to summarize the role of cytochrome P450 (CYP) genetic variants in the …

Major depressive disorder is an often chronic and recurring illness. Left untreated, major
depressive disorder may result in progressive alterations in brain morphometry and circuit …

In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

Escitalopram is one of the most commonly used antidepressant drugs but exhibits a
substantial interindividual variation in clinical response. A key factor underlying response …