Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Disseminated intravascular coagulation (DIC) is a condition characterized by systemic
activation of coagulation, potentially leading to thrombotic obstruction of small and midsize …

Tumor lysis syndrome (TLS) is a serious, sometimes life-threatening oncologic emergency
caused by rapid and massive cellular lysis and subsequent release of tumor cell contents …

Coagulopathy is a severe and frequent complication in critically ill patients, for which the
pathogenesis and presentation may be variable depending on the underlying disease …

The application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has
revolutionized the treatment of acute promyelocytic leukemia (APL). More than 80–90% of …

Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)–retinoic
acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling …

Coagulopathy occurs in most patients with (APML) and is life‐threatening; therefore prompt
diagnosis and recognition of any coagulation defect is imperative. Unfortunately …

Disseminated intravascular coagulation (DIC) has been understood as a consumptive
coagulopathy. However, impaired hemostasis is a component of DIC that occurs in a …

Microparticles (MPs) represent a heterogeneous population of submicronic vesicles that are
released in response to cell activation or apoptosis. MPs harbor a large repertoire of cell …