Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects

M Switonski, M Mankowska, S Salamon - Journal of applied genetics, 2013 - Springer
The melanocortin receptor gene family consists of five single-exon members, which are
located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human …

Genetics of fat tissue accumulation in pigs: a comparative approach

M Switonski, M Stachowiak, J Cieslak, M Bartz… - Journal of Applied …, 2010 - Springer
Fatness traits are important in pig production since they influence meat quality and fattening
efficiency. On the other hand, excessive fat accumulation in humans has become a serious …

A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc‐Pietrain resource population

G Liu, DGJ Jennen, E Tholen, H Juengst… - Animal …, 2007 - Wiley Online Library
We performed a genome‐wide QTL scan for production traits in a line cross between Duroc
and Pietrain breeds of pigs, which included 585 F2 progeny produced from 31 full‐sib …

A critical analysis of production-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig

EM Ibeagha-Awemu, P Kgwatalala, X Zhao - Mammalian Genome, 2008 - Springer
Increasing productivity is one of the main objectives in animal production. Traditional
breeding methods have led to increased gains in some traits but gains are not easily …

Effects of melanocortin-4 receptor gene on growth and meat traits in pigs raised in Russia.

A Klimenko, A Usatov, L Getmantseva, Y Kolosov… - 2014 - cabidigitallibrary.org
Abstract The Melanocortin-4 Receptor (MC4R), a G-protein coupled receptor, is implicated
in mediating the effect of leptin on food intake and energy balance. A previous candidate …

Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs …

L Fontanesi, G Galimberti, DG Calo… - Journal of Animal …, 2012 - academic.oup.com
Combining different approaches (resequencing of portions of 54 obesity candidate genes,
literature mining for pig markers associated with fat deposition or related traits in 77 genes …

Mutations of MC4R gene and its association with economic traits in Qinchuan cattle

H Liu, W Tian, L Zan, H Wang, H Cui - Molecular Biology Reports, 2010 - Springer
MC4R belongs to a seven-transmembrane G-protein-coupled receptor which may regulate
body composition and insulin action. Many mutations in the MC4R gene are associated with …

Analysis of MC4R polymorphism in Italian Large White and Italian Duroc pigs: association with carcass traits

R Davoli, S Braglia, V Valastro, C Annarratone… - Meat science, 2012 - Elsevier
The melanocortin-4 receptor (MC4R) gene codes for a G protein transmembrane receptor
playing an important role in energy homeostasis control. In pig a single nucleotide …

Detailed characterization of the porcine MC4R gene in relation to fatness and growth

B Fan, SK Onteru, GS Plastow… - Animal genetics, 2009 - Wiley Online Library
In contrast to the human MC4R gene, where multiple variants have been described, several
of which are associated with appetite and obesity, few MC4R variants have been reported in …

Possible effects of the MC4R Asp298Asn polymorphism on pig production traits under ad libitum versus restricted feeding

J Calta, K Zadinová, J Čítek… - Journal of Animal …, 2023 - Wiley Online Library
Abstract The missense mutation Asp298Asn in the melanocortin 4 receptor (MC4R) is
associated with daily gain or fatness in pigs (Sus scrofa domesticus). However, to the best of …