Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral
antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging …
antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging …
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody
A Zibat, X Zhang, A Dickmanns, KM Stegmann… - Iscience, 2023 - cell.com
Summary N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is
incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an" …
incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an" …
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface
Identifying virus-host interactions on the cell surface can improve our understanding of viral
entry and pathogenesis. SARS-CoV-2, the causative agent of the COVID-19 disease, uses …
entry and pathogenesis. SARS-CoV-2, the causative agent of the COVID-19 disease, uses …
Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors
The COVID-19 pandemic is caused by SARS-CoV-2, a highly transmissible and pathogenic
RNA betacoronavirus. Like other RNA viruses, SARS-CoV-2 continues to evolve with or …
RNA betacoronavirus. Like other RNA viruses, SARS-CoV-2 continues to evolve with or …
Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2
H Kinoshita, T Yamamoto, Y Kuroda, Y Inoue… - Scientific reports, 2024 - nature.com
The cell culture-based isolation of novel coronavirus SARS-CoV-2 from clinical specimens
obtained from patients with suspected COVID-19 is important not only for laboratory …
obtained from patients with suspected COVID-19 is important not only for laboratory …
Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis
Coronaviruses are highly transmissible respiratory viruses that cause symptoms ranging
from mild congestion to severe respiratory distress. The recent outbreak of severe acute …
from mild congestion to severe respiratory distress. The recent outbreak of severe acute …
[HTML][HTML] The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction
A Bogoyavlenskiy, P Alexyuk, M Alexyuk, V Berezin… - Viruses, 2024 - mdpi.com
The global burden of COVID-19 continues to rise, and despite significant progress in
vaccine development, there remains a critical need for effective treatments for the severe …
vaccine development, there remains a critical need for effective treatments for the severe …
Molecular Genetic Assessment of Nodular Dermatitis Virus in Cattle Herds
L Gnezdilova, V Laga, S Marzanova… - Advancements in Life …, 2024 - als-journal.com
Background: The study highlights the significance of data availability in molecular genetic
research, focusing on cattle nodular dermatitis virus. Limited data on Russian genetic …
research, focusing on cattle nodular dermatitis virus. Limited data on Russian genetic …
Introduction to Animal Cell Culture
Animal cell culture has marked a significant revolution in science, allowing different fields to
benefit from its use. The aim of this chapter is to introduce animal cell culture, covering its …
benefit from its use. The aim of this chapter is to introduce animal cell culture, covering its …
Preferential apical infection of intestinal cell monolayers by SARS-CoV-2 is associated with damage to cellular barrier integrity: Implications for the physiopathology of …
C Garrec, J Arrindell, J Andrieu, B Desnues, JL Mege… - bioRxiv, 2024 - biorxiv.org
SARS-CoV-2 can infect different organs, including the intestine. In Caco-2 intestinal cell line,
SARS-CoV-2 modulates the ACE2 receptor expression and affects the expression of …
SARS-CoV-2 modulates the ACE2 receptor expression and affects the expression of …