The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information
transfer at most excitatory synapses in the brain. Crystal structures are now available for the …

Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic
transmissions within the mammalian central nervous system (CNS). As for other ion channel …

Using trio whole-exome sequencing, we have identified de novo heterozygous pathogenic
variants in GRIA4 in five unrelated individuals with intellectual disability and other …

The NMDA receptor plays a critical role in the development of the central nervous system
and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this …

The ionotropic glutamate receptors (iGluRs) represent a major family of ion channels whose
quaternary structure has not yet been defined. Here, we present the three-dimensional …

Ionotropic glutamate receptors (iGluRs) are ligand-gated cation channels that mediate fast
excitatory neurotransmission in the mammalian central nervous system. In the model plant …

NMDA receptors mediate excitatory neurotransmission in brain and spinal cord and play a
pivotal role in the neurological disease state of chronic pain, which is caused by central …