It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

Background: Given the importance of microvascular injury in infarct formation and
expansion, development of therapeutic strategies for microvascular protection against …

Macrophage is one of the important players in immune response which perform many
different functions during tissue injury, repair, and regeneration. Studies using animal …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Oxidative post-translational modifications (oxPTM) of receptors, enzymes, ion channels and
transcription factors play an important role in cell signaling. oxPTMs are a key way in which …

Mouse hindlimb ischemia has been widely used as a model to study peripheral artery
disease. Genetic modulation of the enzymatic source of oxidants or components of the …

Reactive oxygen species (ROS) are produced in various cell compartments by an array of
enzymes and processes. An excess of ROS production can be hazardous for normal cell …

The safety evaluation of silica nanoparticles (SiNPs) are getting great attention due to its
widely-used in food sciences, chemical industry and biomedicine. However, the adverse …