A Review of the Important Role of CYP2D6 in Pharmacogenomics

C Taylor, I Crosby, V Yip, P Maguire, M Pirmohamed… - Genes, 2020 - mdpi.com
Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~
20% of commonly used drugs across a broad spectrum of medical disciplines including …

Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review

M Andargie, M Vinas, A Rathgeb, E Möller, P Karlovsky - Molecules, 2021 - mdpi.com
Major lignans of sesame sesamin and sesamolin are benzodioxol--substituted furofurans.
Sesamol, sesaminol, its epimers, and episesamin are transformation products found in …

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

MS Wu, LBB Aquino, MYU Barbaza, CL Hsieh… - Molecules, 2019 - mdpi.com
The use of foodstuff as natural medicines has already been established through studies
demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and …

The relationship of antioxidant components and antioxidant activity of sesame seed oil

Y Wan, H Li, G Fu, X Chen, F Chen… - Journal of the Science of …, 2015 - Wiley Online Library
Although sesame seed oil contains high levels of unsaturated fatty acids and even a small
amount of free fatty acids in its unrefined flavored form, it shows markedly greater stability …

A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum)

AF Majdalawieh, M Massri, GK Nasrallah - European journal of …, 2017 - Elsevier
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed
that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin …

[HTML][HTML] Recent progress in the thermal treatment of oilseeds and oil oxidative stability: A review

Z Cai, K Li, WJ Lee, MTJ Reaney, N Zhang… - Fundamental …, 2021 - Elsevier
Oxidative deterioration of vegetable oils is of great importance in the food industry. In China,
vegetable oils produced via thermal pretreatment are popular owing to their strong oil flavor …

Drug–nutrient interactions: a broad view with implications for practice

JI Boullata, LM Hudson - Journal of the Academy of Nutrition and Dietetics, 2012 - Elsevier
The relevance of drug− nutrient interactions in daily practice continues to grow with the
widespread use of medication. Interactions can involve a single nutrient, multiple nutrients …

Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

AF Majdalawieh, SM Yousef… - Critical reviews in …, 2022 - Taylor & Francis
Inflammation is associated with the development and progression of various disorders
including atherosclerosis, diabetes mellitus and cancer. Sesamin, a fat-soluble lignan …

Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway

CM Liu, GH Zheng, QL Ming, C Chao… - Journal of agricultural …, 2013 - ACS Publications
Sesamin (Ses), one of the major lignans in sesame seeds and oil, has been reported to
have many benefits and medicinal properties. However, its protective effects against nickel …

Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450

V Burkina, MK Rasmussen, N Pilipenko… - Toxicology, 2017 - Elsevier
Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical
role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure …