The blood-brain barrier (BBB) plays a critical role in maintaining ion and fluid homeostasis,
essential for brain metabolism and neuronal function. Regulation of nutrient, water, and ion …

Calcium-activated potassium (KCa) channels are ubiquitously expressed throughout the
body and are able to regulate membrane potential and intracellular calcium concentrations …

Ca2+ signalling plays a crucial role in determining lymphatic muscle cell excitability and
contractility through its interaction with the Ca2+‐activated Cl− channel anoctamin 1 (ANO1) …

Individuals aged≥ 65 yr will comprise∼ 20% of the global population by 2030.
Cardiovascular disease remains the leading cause of death in the world with age-related …

Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) act together to regulate
blood pressure and systemic blood flow by appropriately adjusting blood vessel diameter in …

Capillaries are the smallest blood vessels (< 10 μm in diameter) in the body and their walls
are lined by endothelial cells. These microvessels play a crucial role in nutrient and gas …

INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing
hemodynamic regulation. Large conductance Ca2+‐activated K+ channels (BKCa) regulate …

Objective Cerebral blood flow (CBF) decline is increasingly recognized as an area of
importance for targeting neurodegenerative disorders, yet full understanding of the …

Cerebral microvascular dysfunction and nitro-oxidative stress are present in patients with
Alzheimer's disease (AD) and may contribute to disease progression and severity. Large …

Oxidative stress impairs vascular function in the brain and has been linked to
neurodegenerative diseases, such as Alzheimer's Disease (AD). Peroxynitrite is an oxidant …