Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ inflammatory damage and wide spectrum of autoantibodies. The autoantibodies …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by
Adjuvants' was defined pointing to summarize for the first time the spectrum of immune …

PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP
system to generate a T cell-specific deletion of the Pten gene (Pten flox/− mice). All Pten …

Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a
murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody …

Antibodies to DNA are of interest to a broad spectrum of physicians and other scientists. The
presence of large amounts of serum antibodies to double-stranded DNA is specific for …

Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents
and to restrict autoimmune responses against self antigens. Although factors participating in …

Lupus is a complex heterogeneous disease characterised by autoantibody production and
immune complex deposition followed by damage to target tissues. Animal models of human …

Some adjuvants may exert adverse effects upon injection or, on the other hand, may not
trigger a full immunological reaction. The mechanisms underlying adjuvant adverse effects …

Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous
autoimmune disease that most often afflicts women in their child-bearing years. It is …