The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

This protocol describes the use of TurboID and split-TurboID in proximity labeling
applications for mapping protein–protein interactions and subcellular proteomes in live …

Skeletal aging is characterized by low bone turnover and marrow fat accumulation.
However, the underlying mechanism for this imbalance is unclear. Here, we show that …

The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine
mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion …

Mitochondria are dynamic organelles that undergo membrane remodeling events in
response to metabolic alterations to generate an adequate mitochondrial network. Here, we …

Proteins are workhorses in the cell; they form stable and more often dynamic, transient
protein–protein interactions, assemblies, and networks and have an intimate interplay with …

Oncomodulin (Ocm) is a myeloid cell–derived growth factor that enables axon regeneration
in mice and rats after optic nerve injury or peripheral nerve injury, yet the mechanisms …

Host–virus protein–protein interactions play key roles in the life cycle of severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We conducted a comprehensive …