Saturated five-membered thiazolidines and their derivatives: from synthesis to biological applications

N Sahiba, A Sethiya, J Soni, DK Agarwal… - Topics in Current …, 2020 - Springer
In past decades, interdisciplinary research has been of great interest for scholars.
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …

An insight into the synthesis and SAR of 2, 4-thiazolidinediones (2, 4-TZD) as multifunctional scaffold: a review

NS Sethi, DN Prasad, RK Singh - Mini Reviews in Medicinal …, 2020 - ingentaconnect.com
2, 4-Thiazolidinedione (2, 4-TZD) is a versatile pharmacophore, a privileged scaffold, and a
remarkable sulphur-containing heterocyclic compound with diverse pharmacological …

A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth

S Calis, B Dogan, S Durdagi, A Celebi, O Yapicier… - Cell Death …, 2022 - nature.com
Anti-apoptotic members of the Bcl-2 family proteins play central roles in the regulation of cell
death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances …

Microwave assisted synthesis of chalcone and its polycyclic heterocyclic analogues as promising antibacterial agents: In vitro, in silico and DFT studies

SA Khan, AM Asiri, NSM Al-Ghamdi, M Asad… - Journal of Molecular …, 2019 - Elsevier
Microwave assisted condensation of 3-acetyl-2, 5-dimethylthiophene (1) and 9-ethyl-9H-
carbazole-3-carbaldehyde (2) gave 1-(2, 5-Dimethylthiophen-3-yl)-3-(9-ethyl-9H-carbazol-3 …

[HTML][HTML] 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling

ESP Aranha, AJ de Sousa Portilho, LB de Sousa… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance 22β-hydroxytingenone (22-HTG) is a
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …

Antibacterial and antibiofilm activities of thiazolidine‐2, 4‐dione and 4‐thioxo‐thiazolidin‐2‐one derivatives against multidrug‐resistant Staphylococcus aureus clinical …

KXFR Sena, RFV Mendes, EX Bôtelho… - Journal of Applied …, 2022 - academic.oup.com
Aims Antimicrobial resistance is one of the highest priorities in global public health with
Staphylococcus aureus among the most important microorganisms due to its rapidly …

Synthesis of hybrids thiazole–quinoline, thiazole–indole and their analogs: in vitro anti-proliferative effects on cancer cell lines, DNA binding properties and molecular …

PFS Santos-Junior, IJS Nascimento… - New Journal of …, 2021 - pubs.rsc.org
A convenient synthesis under ultrasound (US) irradiation of 4-thiazolidinone, thiazole,
dihydrothiazole, and thiazine hybrid compounds containing quinoline and indole nucleus is …

Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from Curcuma comosa Rhizomes on Leukaemic Cells

N Viriyaadhammaa, A Saiai, W Neimkhum… - Molecules, 2020 - mdpi.com
Curcuma comosa belongs to the Zingiberaceae family. In this study, two natural compounds
were isolated from C. comosa, and their structures were determined using nuclear magnetic …

Synthesis and cytotoxic evaluation of novel brominated N‐alkyl pyrano[3,2‐c]quinolinones

SM Hassan, JM Morsy, HM Hassanin… - Journal of …, 2021 - Wiley Online Library
A novel series of 6‐alkyl‐4‐bromopyrano [3, 2‐c] quinoline‐2, 5‐diones (2a–c), 6‐alkyl‐3, 4‐
dibromopyrano [3, 2‐c] quinoline‐2, 5‐diones (4a–c), and 6‐alkyl‐3‐amino‐bromopyrano …

A Novel Drug Modulator Diarylheptanoid (trans-1,7-Diphenyl-5-hydroxy-1-heptene) from Curcuma comosa Rhizomes for P-glycoprotein Function and Apoptosis …

N Viriyaadhammaa, S Duangmano, A Saiai… - International Journal of …, 2022 - mdpi.com
Curcuma comosa has been used in traditional Thai medicine to treat menstrual cycle-related
symptoms in women. This study aims to evaluate the diarylheptanoid drug modulator, t rans …