Transcriptional riboswitches integrate timescales for bacterial gene expression control
CE Scull, SS Dandpat, RA Romero… - Frontiers in molecular …, 2021 - frontiersin.org
Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′
untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures …
untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures …
The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field
M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …
annual meeting series focused on presenting the latest research achievements involving …
Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble
T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …
A bio-hybrid DNA rotor–stator nanoengine that moves along predefined tracks
Biological motors are highly complex protein assemblies that generate linear or rotary
motion, powered by chemical energy. Synthetic motors based on DNA nanostructures, bio …
motion, powered by chemical energy. Synthetic motors based on DNA nanostructures, bio …
Monitoring RNA dynamics in native transcriptional complexes
A Chauvier, P St-Pierre, JF Nadon… - Proceedings of the …, 2021 - National Acad Sciences
Cotranscriptional RNA folding is crucial for the timely control of biological processes, but
because of its transient nature, its study has remained challenging. While single-molecule …
because of its transient nature, its study has remained challenging. While single-molecule …
Mg2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection
KC Suddala, J Wang, Q Hou… - Journal of the American …, 2015 - ACS Publications
Bacterial riboswitches couple small-molecule ligand binding to RNA conformational
changes that widely regulate gene expression, rendering them potential targets for antibiotic …
changes that widely regulate gene expression, rendering them potential targets for antibiotic …
Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation
Cotranscriptional RNA folding is widely assumed to influence the timely control of gene
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …
Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics
PreQ1-III riboswitches are newly identified RNA elements that control bacterial genes in
response to preQ1 (7-aminomethyl-7-deazaguanine), a precursor to the essential …
response to preQ1 (7-aminomethyl-7-deazaguanine), a precursor to the essential …
Small-molecule-binding riboswitches
TS Lotz, B Suess - Microbiology spectrum, 2018 - Am Soc Microbiol
ABSTRACT RNA is a versatile biomolecule capable of transferring information, taking on
distinct three-dimensional shapes, and reacting to ambient conditions. RNA molecules …
distinct three-dimensional shapes, and reacting to ambient conditions. RNA molecules …
Hierarchical mechanism of amino acid sensing by the T-box riboswitch
KC Suddala, J Cabello-Villegas, M Michnicka… - Nature …, 2018 - nature.com
In Gram-positive bacteria, T-box riboswitches control gene expression to maintain the
cellular pools of aminoacylated tRNAs essential for protein biosynthesis. Co-transcriptional …
cellular pools of aminoacylated tRNAs essential for protein biosynthesis. Co-transcriptional …