Transcriptional riboswitches integrate timescales for bacterial gene expression control

CE Scull, SS Dandpat, RA Romero… - Frontiers in molecular …, 2021 - frontiersin.org
Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′
untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures …

The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field

M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …

Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble

KC Suddala, J Yoo, L Fan, X Zuo, YX Wang… - Nature …, 2023 - nature.com
T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …

A bio-hybrid DNA rotor–stator nanoengine that moves along predefined tracks

J Valero, N Pal, S Dhakal, NG Walter… - Nature …, 2018 - nature.com
Biological motors are highly complex protein assemblies that generate linear or rotary
motion, powered by chemical energy. Synthetic motors based on DNA nanostructures, bio …

Monitoring RNA dynamics in native transcriptional complexes

A Chauvier, P St-Pierre, JF Nadon… - Proceedings of the …, 2021 - National Acad Sciences
Cotranscriptional RNA folding is crucial for the timely control of biological processes, but
because of its transient nature, its study has remained challenging. While single-molecule …

Mg2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection

KC Suddala, J Wang, Q Hou… - Journal of the American …, 2015 - ACS Publications
Bacterial riboswitches couple small-molecule ligand binding to RNA conformational
changes that widely regulate gene expression, rendering them potential targets for antibiotic …

Dynamic competition between a ligand and transcription factor NusA governs riboswitch-mediated transcription regulation

A Chauvier, P Ajmera, R Yadav… - Proceedings of the …, 2021 - National Acad Sciences
Cotranscriptional RNA folding is widely assumed to influence the timely control of gene
expression, but our understanding remains limited. In bacteria, the fluoride (F−)-sensing …

Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics

JA Liberman, KC Suddala, A Aytenfisu… - Proceedings of the …, 2015 - National Acad Sciences
PreQ1-III riboswitches are newly identified RNA elements that control bacterial genes in
response to preQ1 (7-aminomethyl-7-deazaguanine), a precursor to the essential …

Small-molecule-binding riboswitches

TS Lotz, B Suess - Microbiology spectrum, 2018 - Am Soc Microbiol
ABSTRACT RNA is a versatile biomolecule capable of transferring information, taking on
distinct three-dimensional shapes, and reacting to ambient conditions. RNA molecules …

Hierarchical mechanism of amino acid sensing by the T-box riboswitch

KC Suddala, J Cabello-Villegas, M Michnicka… - Nature …, 2018 - nature.com
In Gram-positive bacteria, T-box riboswitches control gene expression to maintain the
cellular pools of aminoacylated tRNAs essential for protein biosynthesis. Co-transcriptional …