The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
R Ke, Q Xu, C Li, L Luo, D Huang - Cell Biology International, 2018 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is a conserved sensor of cellular energy change and
is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy …
is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy …
[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
Cancer stem cell definitions and terminology: the devil is in the details
P Valent, D Bonnet, R De Maria, T Lapidot… - Nature Reviews …, 2012 - nature.com
The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …
investigation has been hampered both by a lack of consistency in the terms used for these …
SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond
T Schaefer, C Lengerke - Oncogene, 2020 - nature.com
Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …
Salinomycin as a drug for targeting human cancer stem cells
C Naujokat, R Steinhart - BioMed Research International, 2012 - Wiley Online Library
Cancer stem cells (CSCs) represent a subpopulation of tumor cells that possess self‐
renewal and tumor initiation capacity and the ability to give rise to the heterogenous …
renewal and tumor initiation capacity and the ability to give rise to the heterogenous …
[HTML][HTML] Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance
JA McCubrey, LS Steelman, WH Chappell… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
Autophagy in stem cells
Autophagy is a highly conserved cellular process by which cytoplasmic components are
sequestered in autophagosomes and delivered to lysosomes for degradation. As a major …
sequestered in autophagosomes and delivered to lysosomes for degradation. As a major …
Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia
SK Tasian, DT Teachey, Y Li, F Shen… - Blood, The Journal …, 2017 - ashpublications.org
Philadelphia chromosome (Ph)–like B-cell acute lymphoblastic leukemia (Ph-like ALL) is
associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3 …
associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3 …
Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway
Autophagy plays an important role in cellular homeostasis through the disposal and
recycling of cellular components. Cancer stem cells (CSCs) play major roles in cancer …
recycling of cellular components. Cancer stem cells (CSCs) play major roles in cancer …