Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

Pancreatic cancer (PC) incidence rates are rapidly increasing in developed countries, with
half the patients being metastatic at diagnosis. For decades, fluorouracil, then gemcitabine …

NAF‐1 (nutrient‐deprivation autophagy factor‐1), which is an outer mitochondrial membrane
protein, is known to play important roles in calcium metabolism, antiapoptosis, and …

Activation of pancreatic stellate cells (PSCs) initiates pancreatic fibrosis in chronic
pancreatitis and furnishes a niche that enhances the malignancy of pancreatic cancer cells …

Purpose In recent years, significant progress in survival has been achieved using systemic
combination chemotherapy in patients with pancreatic cancer. However, the elderly are …

Objectives Pancreatic cancer is a highly lethal disease predominantly affecting older
patients. Characterization of outcomes in these patients may help optimise treatment …

Introduction With the prolongation of life expectancy, an increasing number of elderly
patients are evaluated for pancreatic surgery. However, the influence of increasing age on …

Objectives Older patients make up the majority of patients with pancreatic cancer, with a
median age of 71 years at diagnosis. However, older patients are underrepresented in …

Simple Summary Pancreatic adenocarcinoma is an aggressive tumour with a high mortality,
often diagnosed at advanced stages. The current standard of care for first-line therapy is …

Pancreatic cancer is still one of the most lethal cancers with a reported 5-year relative
survival rate of approximatively 9% and medical treatment remains a major challenge …