Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …

Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients
with a single gene defect. This rare variant of lupus generally presents with early onset …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which
underlies many chronic diseases. Although mitochondrial damage is needed for the …

Chronic hepatitis B virus (HBV) infection puts more than 250 million people at a greatly
increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates …

The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE)
manifests before the age of 16 years in 10–20% of all cases. Clinical courses are more …

SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the
autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I …

In a lifetime, a human being synthesizes approximately 2× 1016 meters of DNA, a distance
that corresponds to 130,000 times the distance between the Earth and the Sun. This …

Rationale: Viruses hijack the host cell machinery to promote viral replication; however, the
mechanism by which metabolic reprogramming regulates innate antiviral immunity in the …

SAMHD1 limits HIV-1 infection in non-dividing myeloid cells by decreasing intracellular
dNTP pools. HIV-1 restriction by SAMHD1 in these cells likely prevents activation of antiviral …