Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by
cognitive decline and progressive memory loss. The aim of this review was to update the …

Inhibition of fibril formation is considered a possible treatment strategy for amyloid-related
diseases. Understanding the molecular nature of inhibitor action is crucial for the design of …

Calcium ion regulation plays a crucial role in maintaining neuronal functions such as
neurotransmitter release and synaptic plasticity. Copper (Cu2+) coordination to amyloid‐β …

Alzheimer's disease (AD) is a neuropathology characterized by progressive cognitive
impairment and dementia. The disease is attributed to senile plaques, which are aggregates …

The pathological assembly of intrinsically disordered proteins/peptides (IDPs) into amyloid
fibrils is associated with a range of human pathologies, including neurodegeneration …

Selectivity profiling is key for assessing the pharmacological properties of multi-target drugs.
We have developed a cell-based and barcoded assay encompassing ten druggable targets …

Amyloid-β (Aβ1–42) peptides aggregated into plaques deposited in the brain are the main
hallmark of Alzheimer's disease (AD), a social and economic burden worldwide. In this …

Fibrillation of proteins and polypeptides, which leads to the deposition of plaques in cells
and tissues has been widely associated with many neuropathological diseases. Inhibition of …

Abstract Background Kai-Xin-San (KXS) has been reported to have a good curative impact
on dementia. The purpose of the study was to determine whether KXS might ameliorate …

The assembly of the amyloid-β peptide (A β) into toxic oligomers and fibrils is associated
with Alzheimer's disease and dementia. Therefore, disrupting amyloid assembly by direct …