Many patients with cancer suffer from anemia, depression, and an impaired quality of life
(QoL). These patients often also show decreased plasma tryptophan levels and increased …

This systematic review and meta-analysis provides epidemiological data on the relationship
between chronic inflammation, as measured by inflammatory blood parameters, and cancer …

[Objective] Using multi-omics research methods to explore cytolytic activity-related genes
through the immunoregulatory factors HAVCR2 (TIM3) affecting the survival and prognosis …

OBJECTIVE We sought to study the associations between plasma metabolites in the
tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease …

The enzyme indoleamine 2, 3-dioxygenase 1 (IDO1) degrade tryptophan (Trp) into
kynurenine (Kyn) at the initial step of an enzymatic pathway affecting T cell proliferation …

Lung cancer is the most lethal malignancy worldwide. Recently, it has been recognized that
metabolic reprogramming is a complex and multifaceted factor, contributing to the process of …

Differential diagnosis of pulmonary nodules detected by computed tomography (CT)
remains a challenge in clinical practice. Here, we characterize the global metabolomes of …

ABSTRACT The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL)
program is an NCI-funded initiative with an objective to develop tools to optimize low-dose …

Objectives The COVID-19 pandemic has been a serious worldwide public health crisis since
2020 and is still challenging healthcare systems. New tools for the prognosis and diagnosis …

Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine
pathway of tryptophan metabolism increase during inflammation, particularly in response to …