Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera, S Kathiresan - Nature Reviews Genetics, 2017 - nature.com
Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …
heritable, recent advances have started to unravel the genetic architecture of the disease …
A decade of genome-wide association studies for coronary artery disease: the challenges ahead
J Erdmann, T Kessler, L Munoz Venegas… - Cardiovascular …, 2018 - academic.oup.com
In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …
based on 10 years of genome-wide association studies. The discoveries began with …
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease
To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …
Genetic risk, adherence to a healthy lifestyle, and coronary disease
Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle …
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Large-scale association analysis identifies new risk loci for coronary artery disease
CARDIoGRAMplusC4D Consortium, P Deloukas… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide,.
Although 58 genomic regions have been associated with CAD thus far,,,,,,, most of the …
Although 58 genomic regions have been associated with CAD thus far,,,,,,, most of the …
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
DI Swerdlow, KB Kuchenbaecker… - International journal …, 2016 - academic.oup.com
Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …
environmental exposures or disease biomarkers, using genetic variants that instrument …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …