[HTML][HTML] The urothelium: a multi-faceted barrier against a harsh environment

NV Jafari, JL Rohn - Mucosal Immunology, 2022 - Elsevier
All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …

[HTML][HTML] Molecular diagnostic methods versus conventional urine culture for diagnosis and treatment of urinary tract infection: a systematic review and meta-analysis

A Szlachta-McGinn, KM Douglass, UYR Chung… - European Urology Open …, 2022 - Elsevier
Context Urine culture has low sensitivity in the diagnosis of urinary tract infection (UTI). Next-
generation sequencing (NGS) and polymerase chain reaction (PCR) are culture …

A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals

C Flores, J Ling, A Loh, RG Maset, A Aw, IJ White… - Science …, 2023 - science.org
Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …

Diagnosis and treatment of culture-negative periprosthetic joint infection

GS Goh, J Parvizi - The Journal of Arthroplasty, 2022 - Elsevier
Identification of the causative organism (s) in periprosthetic joint infection (PJI) is a
challenging task. The shortcomings of traditional cultures have been emphasized in recent …

[HTML][HTML] The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection

CCY Chieng, Q Kong, NSY Liou, R Khasriya… - Mucosal …, 2023 - Elsevier
Urinary tract infections (UTIs) exert a significant health and economic cost globally.
Approximately one in four people with a previous history of UTI continue to develop …

Urinary microbiome of reproductive-age asymptomatic European women

S Ugarcina Perovic, M Ksiezarek, J Rocha… - Microbiology …, 2022 - Am Soc Microbiol
The knowledge of bacterial species diversity within the female urinary microbiome (FUM) is
essential for understanding the role of the FUM in urinary tract health and disease. This …

An immunoresponsive three-dimensional urine-tolerant human urothelial model to study urinary tract infection

NV Jafari, JL Rohn - Frontiers in cellular and infection microbiology, 2023 - frontiersin.org
Introduction Murine models of urinary tract infection (UTI) have improved our understanding
of host-pathogen interactions. However, given differences between rodent and human …

Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women

LA Burnett, BR Hochstedler, K Weldon… - Neurourology and …, 2021 - Wiley Online Library
Aims Clinical profiles of women with recurrent urinary tract infection (RUTI) are correlated
with their urinary microbes. Methods This IRB‐approved, cross‐sectional study enrolled …

Alpha-diversity and microbial community structure of the male urinary microbiota depend on urine sampling method

J Hrbacek, D Morais, P Cermak, V Hanacek… - Scientific Reports, 2021 - nature.com
Considerable variation exists in the methodology of urinary microbiota studies published so
far including the cornerstone of any biomedical analysis: sample collection. The aim of this …

Antibiotic management of urinary tract infections in the post-antibiotic era: a narrative review highlighting diagnostic and antimicrobial stewardship

IJ Abbott, TN Peel, KA Cairns, AJ Stewardson - Clinical Microbiology and …, 2023 - Elsevier
Background As one of the most common indications for antimicrobial prescription in the
community, the management of urinary tract infections (UTIs) is both complicated by, and a …