[HTML][HTML] The urothelium: a multi-faceted barrier against a harsh environment
NV Jafari, JL Rohn - Mucosal Immunology, 2022 - Elsevier
All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …
[HTML][HTML] Molecular diagnostic methods versus conventional urine culture for diagnosis and treatment of urinary tract infection: a systematic review and meta-analysis
A Szlachta-McGinn, KM Douglass, UYR Chung… - European Urology Open …, 2022 - Elsevier
Context Urine culture has low sensitivity in the diagnosis of urinary tract infection (UTI). Next-
generation sequencing (NGS) and polymerase chain reaction (PCR) are culture …
generation sequencing (NGS) and polymerase chain reaction (PCR) are culture …
A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals
Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …
Diagnosis and treatment of culture-negative periprosthetic joint infection
Identification of the causative organism (s) in periprosthetic joint infection (PJI) is a
challenging task. The shortcomings of traditional cultures have been emphasized in recent …
challenging task. The shortcomings of traditional cultures have been emphasized in recent …
[HTML][HTML] The clinical implications of bacterial pathogenesis and mucosal immunity in chronic urinary tract infection
CCY Chieng, Q Kong, NSY Liou, R Khasriya… - Mucosal …, 2023 - Elsevier
Urinary tract infections (UTIs) exert a significant health and economic cost globally.
Approximately one in four people with a previous history of UTI continue to develop …
Approximately one in four people with a previous history of UTI continue to develop …
Urinary microbiome of reproductive-age asymptomatic European women
S Ugarcina Perovic, M Ksiezarek, J Rocha… - Microbiology …, 2022 - Am Soc Microbiol
The knowledge of bacterial species diversity within the female urinary microbiome (FUM) is
essential for understanding the role of the FUM in urinary tract health and disease. This …
essential for understanding the role of the FUM in urinary tract health and disease. This …
An immunoresponsive three-dimensional urine-tolerant human urothelial model to study urinary tract infection
NV Jafari, JL Rohn - Frontiers in cellular and infection microbiology, 2023 - frontiersin.org
Introduction Murine models of urinary tract infection (UTI) have improved our understanding
of host-pathogen interactions. However, given differences between rodent and human …
of host-pathogen interactions. However, given differences between rodent and human …
Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women
LA Burnett, BR Hochstedler, K Weldon… - Neurourology and …, 2021 - Wiley Online Library
Aims Clinical profiles of women with recurrent urinary tract infection (RUTI) are correlated
with their urinary microbes. Methods This IRB‐approved, cross‐sectional study enrolled …
with their urinary microbes. Methods This IRB‐approved, cross‐sectional study enrolled …
Alpha-diversity and microbial community structure of the male urinary microbiota depend on urine sampling method
J Hrbacek, D Morais, P Cermak, V Hanacek… - Scientific Reports, 2021 - nature.com
Considerable variation exists in the methodology of urinary microbiota studies published so
far including the cornerstone of any biomedical analysis: sample collection. The aim of this …
far including the cornerstone of any biomedical analysis: sample collection. The aim of this …
Antibiotic management of urinary tract infections in the post-antibiotic era: a narrative review highlighting diagnostic and antimicrobial stewardship
Background As one of the most common indications for antimicrobial prescription in the
community, the management of urinary tract infections (UTIs) is both complicated by, and a …
community, the management of urinary tract infections (UTIs) is both complicated by, and a …