Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Geroscience is becoming a major hope for preventing age-related diseases and loss of
function by targeting biological mechanisms of aging. This unprecedented paradigm shift …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …