Axelrod et al.(1958) first described the enzyme-catalyzed O-methylation of catecholamines
and other catechols in the late 1950s. The enzyme responsible for the O-methylation …

Recent studies are beginning to paint a clear and consistent picture of the impairments in
psychological and cognitive competencies that are associated with microdeletions in …

Responses to pain and other stressors are regulated by interactions between multiple brain
areas and neurochemical systems. We examined the influence of a common functional …

Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary
foragers move slowly on a bacterial lawn and disperse across it, while social foragers move …

Diverse phenotypic associations with the catechol-O-methyltransferase (COMT) Val 158 Met
polymorphism have been reported. We suggest that some of the complex effects of this …

Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in
the metabolic degradation of catecholamines and is considered a candidate for several …

Twin studies indicate that obsessive–compulsive disorder (OCD) is strongly influenced by
additive genetic factors. Yet, molecular genetic association studies have yielded inconsistent …

This review summarizes our current understanding of catechol-o-methyltransferase (COMT)
and how it relates to brain function and schizophrenia. We begin by considering the COMT …

Why do men and women think differently? Why do they behave differently in stressed
situations? Why do women act more emotionally as compared to men? Why do men and …

Several lines of evidence have placed the catechol-O-methyltransferase (COMT) gene in the
limelight as a candidate gene for schizophrenia. One of these is its biochemical function in …