Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Immunotherapies aimed at alleviating the inhibitory constraints on T cells have
revolutionized cancer management. To date, these have focused on the blockade of cell …

The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged
as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a …

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening
infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic …

Although adoptive T‐cell therapy has shown remarkable clinical efficacy in haematological
malignancies, its success in combating solid tumours has been limited. Here, we report that …

Co-ordinated interaction between distinct cell types is a hallmark of successful immune
function. A striking example of this is the carefully orchestrated cooperation between helper …

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder that affects an estimated 30
million people worldwide. It is characterized by the destruction of pancreatic β cells by the …

Therapies that target the function of immune cells have significant clinical efficacy in
diseases such as cancer and autoimmunity. Although functional genomics has accelerated …