Pyrrole: An Essential Framework in the Development of Therapeutic Agents and Insightful Analysis of Structure‐Active Relationships

B Sahu, R Sahu, B Gidwani, A Mishra - ChemistrySelect, 2024 - Wiley Online Library
Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an
extensive lead molecule library. Its broad range of pharmacological profiles has concerned …

[HTML][HTML] Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized …

M Georgieva, E Mateev, I Valkova, H Kuteva… - Molecules, 2024 - mdpi.com
Neurodegenerative diseases such as Parkinson's and Alzheimer's continue to be some of
the most significant challenges in modern medicine. Recent research related to the …

In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes

A Mateeva, M Kondeva-Burdina, E Mateev… - Molecules, 2024 - mdpi.com
In the current study, chromatographic and in silico techniques were applied to investigate
the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl) …

[PDF][PDF] Evaluation of the inhibition performance of pyrrole derivatives against CYP450 isoforms

M Kondeva-Burdina, E Mateev, A Irfan, H Kuteva… - …, 2024 - pharmacia.pensoft.net
Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various
pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro …

Synthesis, Characterization and Biological Activity of New Ligand Derived from 4-‎(Dimethylamino) Benzaldehyde and Nano Copper Complex

EJ Waheed - Baghdad Science Journal, 2024 - bsj.uobaghdad.edu.iq
The general formula of new complexes [M2 (BDS) Cl4] are resulting from the reaction of a
new ligand [N1, N4-bis (1H-benzo [d] imidazol-‎‎ 2-yl)-N1, N4-bis (4-(dimethyl amino) benzyl) …