The ABCA4 protein (then called a “rim protein”) was first identified in 1978 in the rims and
incisures of rod photoreceptors. The corresponding gene, ABCA4, was cloned in 1997, and …

Primary tumors are responsible for 10% of cancer deaths. In most cases, the main cause of
mortality is the formation of metastases. Accumulating evidence suggests that a …

Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that
functions in the capture of light and its conversion into electrical signals in a process known …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

First developed for hematologic disorders, the concept of cancer stem cells (CSCs) was
expanded to solid tumors, including colorectal cancer (CRC). The traditional model of colon …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Apical plasma membrane constituents of mammalian neural stem/progenitor cells have
recently been implicated in maintaining their stem/progenitor cell state. Here, we report that …

Photoreceptors are sensory neurons designed to convert light stimuli into neurological
responses. This process, called phototransduction, takes place in the outer segments (OS) …

Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane
domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue …

Abstract Membrane cholesterol–sphingolipid 'rafts', which are characterized by their
insolubility in the non-ionic detergent Triton X-100 in the cold, have been implicated in the …